| Identification | Back Directory | [Name]
D5D-IN-326 | [CAS]
1236767-85-3 | [Synonyms]
D5D-IN-326
3H-Pyrrolo[2,3-d]pyrimidine-4,6-dione, 5,7-dihydro-2-(2,2,3,3,3-pentafluoropropoxy)-3-[4-(2,2,2-trifluoroethoxy)phenyl]- | [Molecular Formula]
C17H11F8N3O4 | [MDL Number]
MFCD31813702 | [MOL File]
1236767-85-3.mol | [Molecular Weight]
473.27 |
| Hazard Information | Back Directory | [Uses]
D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice[1]. | [Biological Activity]
D5D-IN-326 (Compound-326) is an orally availablepotent and selective inhibitor of delta-5 desaturase (D5D) th at reduces insulin resistance and body weight in a high-f at diet-induced obese mice. It appears th at D5D-IN-326 significantly inhibits the progression of atherosclerosis in the aorta of western-diet fed ApoE knockout (KO) mice. It is called Compound-326 in recent J Pharmacol Exp Ther. 2019 Nov;371(2):290-298. (PMID: 31488602) paper. | [in vivo]
D5D-IN-326 (0.1, 1, and 10 mg/kg, p.o. for 6 weeks) gradually decreases body weight at 10 mg/kg, but lowers doses are not effective in DIO mice after treatment for 6 weeks[1].
D5D-IN-326 (10 mg/kg, p.o. for 6 weeks) also significantly decreases gene expression levels of Ccl2, Cd68, Adgre1, and Il6, decreases epididymal Lep and Adipoq mRNAs which are significantly increased in HFD DIO mice[1]. | [storage]
Store at -20°C | [References]
[1] Yashiro H, et al. A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice. PLoS One. 2016 Nov 10;11(11):e0166198. DOI:10.1371/journal.pone.0166198 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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