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123685-36-9

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123685-36-9 Structure

123685-36-9 Structure
IdentificationBack Directory
[Name]

PD 130883
[CAS]

123685-36-9
[Synonyms]

PD 130883
[Molecular Formula]

C18H15N5O3
[MOL File]

123685-36-9.mol
[Molecular Weight]

349.343
Chemical PropertiesBack Directory
[Melting point ]

254-259 °C
[Boiling point ]

616.5±65.0 °C(Predicted)
[density ]

1.36±0.1 g/cm3(Predicted)
[pka]

3.07±0.20(Predicted)
Hazard InformationBack Directory
[Description]

PD 130883 is a potent lipophilic quinazoline antifolate.
[Uses]

PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
[References]

[1] Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition PMID:1825652
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