| Hazard Information | Back Directory | [Description]
PD 130883 is a potent lipophilic quinazoline antifolate. | [Uses]
PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate. | [References]
[1] Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition PMID:1825652 |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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CHEMICAL LAND21
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82- 2 -783 - 8063 |
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www.chemicalland21.com |
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