| Identification | Back Directory | [Name]
Leukotriene E4-d5 | [CAS]
1240398-14-4 | [Synonyms]
Leukotriene E4-d5
OTZRAYGBFWZKMX-XPGOKVCBSA-N
Leukotriene E4-d5 MaxSpecStandard | [Molecular Formula]
C23H37NO5S | [MDL Number]
MFCD10567081 | [MOL File]
1240398-14-4.mol | [Molecular Weight]
439.61 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -80°C | [solubility ]
DMF: >50 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS (pH 7.2): >100 μg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Leukotriene E4-d5 (LTE4-d5) is intended for use as an internal standard for the quantification of LTE4 by GC- or LC-mass spectrometry. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.1 It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).2 LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.1,3 Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.4,5,6 In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.5
LTE4-d5 MaxSpec® standard is a quantitative grade standard of LTE4-d5 (Item No. 10007858) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTE4-d5 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. | [Uses]
Leukotriene E4-d5 | [storage]
Store at -80°C | [References]
[1] K BERNSTR?M S H. Metabolism of leukotriene D by porcine kidney.[J]. The Journal of Biological Chemistry, 1981, 256 18: 9579-9582.
[2] MALMSTEN C L. Leukotrienes: mediators of inflammation and immediate hypersensitivity reactions.[J]. Critical Reviews in Immunology, 1984, 4 4: 307-334.
[3] LEFER A M. Leukotrienes as mediators of ischemia and shock[J]. Biochemical pharmacology, 1986, 35 2: Pages 123-127. DOI: 10.1016/0006-2952(86)90502-2
[4] M. KUMLIN. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans[J]. Clinical and Experimental Allergy, 1995, 25 5: 467-479. DOI: 10.1111/j.1365-2222.1995.tb01079.x
[5] J M DRAZEN. Recovery of leukotriene E4 from the urine of patients with airway obstruction.[J]. The American review of respiratory disease, 1992, 146 1: 104-108. DOI: 10.1164/ajrccm/146.1.104
[6] M KUMLIN. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.[J]. The American review of respiratory disease, 1992, 146 1: 96-103. DOI: 10.1164/ajrccm/146.1.96
[7] LAURENCE BALAS*. Rapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain[J]. Journal of Medicinal Chemistry, 2019, 62 21: 9961-9975. DOI: 10.1021/acs.jmedchem.9b01463
[8] NAN LIN. Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.[J]. Frontiers in Immunology, 2018: 2565. DOI: 10.3389/fimmu.2018.02565 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
amyjetsci
|
| Tel: |
027-59626688 18771149750 |
| Website: |
https://www.amyjet.com/ |
|