| Identification | Back Directory | [Name]
Leukotriene D4-d5 | [CAS]
1240398-17-7 | [Synonyms]
Leukotriene D4-d5
YEESKJGWJFYOOK-HXHZKDJLSA-N | [Molecular Formula]
C25H40N2O6S | [MDL Number]
MFCD11045833 | [MOL File]
1240398-17-7.mol | [Molecular Weight]
496.66 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -80°C | [solubility ]
DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): .1 mg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Leukotriene D4-d5 (LTD4-d5) is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-MS. LTD4 is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal. | [Uses]
Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
amyjet
|
| Tel: |
4006800868;027-59626688 18371453821;18771149750 |
| Website: |
http://www.amyjet.com/ |
|