ChemicalBook--->CAS DataBase List--->1243266-04-7

1243266-04-7

1243266-04-7 Structure

1243266-04-7 Structure
IdentificationBack Directory
[Name]

Tovetumab
[CAS]

1243266-04-7
[Synonyms]

Tovetumab
Research Grade Tovetumab(DHD16102)
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Tovetumab (MEDI-575) is an anti-PDGFRα monoclonal antibody that selectively blocks the PDGFRα signal transduction. Tovetumab can be used in the research of glioblastoma and non-small cell lung cancer (NSCLC)[1][2].
[in vivo]

Tovetumab (0.6-60 mg/kg, i.v.) blocks the PDGFRα-mediated elimination of PDGF-AA, leading to an increase in circulating PDGF-AA level in Cynomolgus monkeys[1].
Tovetumab (10 mg/kg, i.p., twice a week) inhibits tumor growth in U118 glioma xenografts[2].

Animal Model:Cynomolgus monkey[1]
Dosage:0.6, 6.0, and 60 mg/kg
Administration:Intravenous injection (i.v.)
Result:Induced > 100- fold increases in circulating concentrations of PDGF-AA.
Animal Model:U118 glioma xenografts (CB17 SCID)[2]
Dosage:10 mg/kg
Administration:Intraperitoneal injection (i.p.), twice per week.
Result:Produced 101% inhibition of tumor growth.
[IC 50]

PDGFRα
[References]

[1] Meina Liang, et al. A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy. AAPS J. 2020 Nov 18;23(1):4. DOI:10.1208/s12248-020-00523-3
[2] Naomi Laing, et al. Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer. Mol Pharmacol. 2013 Jun;83(6):1247-56. DOI:10.1124/mol.112.084079
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