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Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocyte growth factor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity[1]. | [in vivo]
Telisotuzumab (ABT-700) (i.p., 2.5-40 mg/kg, twice a week, 90 days) effectively antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in SCID mice with Hs746T cells[1].
| Animal Model: | SCID mice with Hs746T cells[1] | | Dosage: | 2.5-40 mg/kg | | Administration: | i.p., twice a week, 90 days | | Result: | Reduced total and phosphorylated c-Met as well as phosphorylated Akt and Erk.
Complete tumor regression at doses above 10 mg/kg but no effective inhibition of tumor growth at doses below 5mg/kg.
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| [References]
[1] Jieyi Wang, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016 Feb 16;16:105. DOI:10.1186/s12885-016-2138-z |
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