| Identification | Back Directory | [Name]
VU 0364739 hydrochloride | [CAS]
1244639-78-8 | [Synonyms]
VU 0364739 HYDROCHLORIDE
2-Naphthalenecarboxamide, N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [Molecular Formula]
C26H27FN4O2 | [MOL File]
1244639-78-8.mol | [Molecular Weight]
446.52 |
| Hazard Information | Back Directory | [Uses]
VU 0364739 Hydrochloride is a selective, small molecule inhibitor of phopholipase D2. | [References]
[1] ROBERT R. LAVIERI. Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor[J]. Journal of Medicinal Chemistry, 2010, 53 18: 6706-6719. DOI: 10.1021/jm100814g
[2] THOMAS P. MATHEWS. Human Phospholipase D Activity Transiently Regulates Pyrimidine Biosynthesis in Malignant Gliomas[J]. ACS Chemical Biology, 2015, 10 5: 1258-1268. DOI: 10.1021/cb500772c
[3] HANS JÖRG LEIS Werner W. Phospholipase D1 activity is crucial for cytosolic phospholipase A2 –dependent prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells[J]. Prostaglandins, leukotrienes, and essential fatty acids, 2023, 198: Article 102592. DOI: 10.1016/j.plefa.2023.102592 |
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