| Identification | Back Directory | [Name]
Febuxostat-d9 | [CAS]
1246819-50-0 | [Synonyms]
TMX 67-d9
TEI 6720-d9
Febuxostat-d9
[2H9]-Febuxostat
Febuxostat-d9 (2-methylpropoxy-d9)
2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid
2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
Febuxostat D9Q: What is
Febuxostat D9 Q: What is the CAS Number of
Febuxostat D9 Q: What is the storage condition of
Febuxostat D9 Q: What are the applications of
Febuxostat D9 | [Molecular Formula]
C16H16N2O3S | [MDL Number]
MFCD21363615 | [MOL File]
1246819-50-0.mol | [Molecular Weight]
316.375 |
| Chemical Properties | Back Directory | [Melting point ]
>201°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Description]
Febuxostat-d9 is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; Kis = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout. | [Uses]
Febuxostat-d9 is a Labeled compound, intended for use as an internal standard for the quantification of Febuxostat by GC- or LC-mass spectrometry.
| [Uses]
Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. | [storage]
Store at -20°C | [References]
[1] KEN OKAMOTO. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.[J]. The Journal of Biological Chemistry, 2003, 278 3: 1848-1855. DOI: 10.1074/jbc.m208307200
[2] YOSHIO OSADA. Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents[J]. European journal of pharmacology, 1993, 241 2: Pages 183-188. DOI: 10.1016/0014-2999(93)90201-r
[3] YASUHIRO TAKANO . Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase[J]. Life sciences, 2005, 76 16: Pages 1835-1847. DOI: 10.1016/j.lfs.2004.10.031
[4] MANISHA BISHT S S B. Febuxostat: a novel agent for management of hyperuricemia in gout.[J]. Indian Journal of Pharmaceutical Sciences, 2011, 73 6: 597-600. DOI: 10.4103/0250-474x.100231
[5] YUSUKE NAKATSU. The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2015: G42-51. DOI: 10.1152/ajpgi.00443.2014
[6] JOSEPHE A HONORAT. Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.[J]. PLoS ONE, 2017: e0187215. DOI: 10.1371/journal.pone.0187215 |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|