| Identification | Back Directory | [Name]
4-ISOBUTOXY-BENZALDEHYDE | [CAS]
18962-07-7 | [Synonyms]
AKOS B000265
FeBuxostat Impurity 34
4-Isobutoxy-benzaldehyd
p-isobutoxybenzaldehyde
p-iso-Butoxy-benzaldehyd
4-(i-butoxy)benzaldehyde
4-ISOBUTOXY-BENZALDEHYDE
Benzaldehyde, 4-(2-methylpropoxy)-
2-(3-cyano-2-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid | [Molecular Formula]
C11H14O2 | [MDL Number]
MFCD01922006 | [MOL File]
18962-07-7.mol | [Molecular Weight]
178.23 |
| Chemical Properties | Back Directory | [Melting point ]
155℃ | [Boiling point ]
74°C/0.08mm | [density ]
1.018±0.06 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.5344 (589.3 nm 20℃) | [Fp ]
118.9±13.4℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Uses]
4-Isobutoxybenzaldehyde to treat neurodegenerative diseases. | [Synthesis]
Step 2: Preparation of 4-isobutoxybenzaldehyde (Compound XIII)
4-Hydroxybenzaldehyde (10 g, 0.082 mol), potassium carbonate (33.95 g, 0.246 mol) and potassium iodide (1.36 g, 0.008 mol) were suspended in N,N-dimethylformamide (50 mL). Isobutyl bromide (26.7 mL, 0.246 mol) was added to the suspension and the reaction was subsequently heated at 70 °C and protected by nitrogen for 3 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 150 mL of water and then extracted with 300 mL of ethyl acetate. The organic phase was washed five times with 150 mL of 10% NaCl solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 14.3 g (98% yield) of the yellow oily product 4-isobutoxybenzaldehyde (Compound XIII). | [References]
[1] Patent: US2018/37549, 2018, A1. Location in patent: Paragraph 0151
[2] Patent: CN105418460, 2016, A. Location in patent: Paragraph 0053; 0056; 0057; 0058; 0059
[3] Patent: CN108358817, 2018, A. Location in patent: Paragraph 0055; 0056; 0057
[4] Russian Journal of General Chemistry, 2005, vol. 75, # 7, p. 1113 - 1124
[5] Patent: WO2006/36874, 2006, A1. Location in patent: Page/Page column 21 |
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