| Identification | Back Directory | [Name]
MitoB | [CAS]
1247025-84-8 | [Synonyms]
MitoB
MitoB >=98% (HPLC)
(3-boronophenyl)methyl]triphenyl-phosphonium,monobromide | [Molecular Formula]
C25H23BBrO2P | [MDL Number]
MFCD28976194 | [MOL File]
1247025-84-8.mol | [Molecular Weight]
477.138 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.5 mg/ml | [form ]
A crystalline solid | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
MitoB is a ratiometric mass spectrometry probe that can be used for assessing changes in H2O2 within mitochondria in vivo. MitoB contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its arylboronic moiety selectively reacts with H2O2 to produce a phenol product, MitoP. Quantifying the MitoP/MitoB ratio by LC-MS/MS reflects the mitochondrial matrix H2O2 concentration. | [Uses]
MitoB is used as a probe in assessing the changes in hydrogen peroxide within mitochondria in vivo. | [storage]
Store at -20°C | [References]
[1] HELENA M COCHEMé. Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila[J]. Nature Protocols, 2012, 7 5: 946-958. DOI: 10.1038/nprot.2012.035
[2] HELENA M COCHEMé. Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.[J]. Cell metabolism, 2011, 13 3: 340-350. DOI: 10.1016/j.cmet.2011.02.003 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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