| Identification | Back Directory | [Name]
5-[(2R,4S)-2-(2,2-dimethylpropyl)piperidin-4-yl]-1,2-oxazol-3-one | [CAS]
1251841-50-5 | [Synonyms]
AZD6564
5-[(2R,4S)-2-(2,2-dimethylpropyl)piperidin-4-yl]-1,2-oxazol-3-one
3(2H)-Isoxazolone, 5-[(2R,4S)-2-(2,2-dimethylpropyl)-4-piperidinyl]- | [Molecular Formula]
C13H22N2O2 | [MDL Number]
MFCD28411392 | [MOL File]
1251841-50-5.mol | [Molecular Weight]
238.33 |
| Hazard Information | Back Directory | [Description]
AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-?protein interaction. | [Uses]
AZD6564 is an orally active inhibitor for fibrinolysis through disruption of plasma kinase-fibrin interaction. AZD6564 dissolves human plasma clot with an IC50 of 0.44 μM. AZD6564 ameliorates hemorrhage in rats with EC50 of 1.62 μM, and exhibits good pharmacokinetic characteristics in rats[1]. | [References]
[1] Cheng L, et al., Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS Med Chem Lett. 2014 Feb 18;5(5):538-43. DOI:10.1021/ml400526d |
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