| Identification | Back Directory | [Name]
CAY10647 | [CAS]
1253697-49-2 | [Synonyms]
CAY10647
CAY10647 Exclusive
(4-fluorophenyl)(2-(4-methoxyphenyl)-1H-imidazol-4-yl)methanone
(4-fluorophenyl)-[2-(4-methoxyphenyl)-1H-imidazol-5-yl]methanone
Methanone, (4-fluorophenyl)[2-(4-methoxyphenyl)-1H-imidazol-5-yl]- | [Molecular Formula]
C17H13FN2O2 | [MOL File]
1253697-49-2.mol | [Molecular Weight]
296.3 |
| Chemical Properties | Back Directory | [Melting point ]
245-247 °C(Solv: water (7732-18-5); methanol (67-56-1)) | [Boiling point ]
521.2±40.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMSO: 3 mg/ml | [form ]
A crystalline solid | [pka]
10.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization[1]. | [in vivo]
Anti-melanoma agent 3 (10, 30 mg/kg; ip; once a day for 14 days) can significantly inhibit tumor growth in B16-F1 tumor-bearing mice[1].
| [References]
[1] Chen J, et al. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem. 2010 Oct 28;53(20):7414-27. DOI:10.1021/jm100884b |
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