| Identification | Back Directory | [Name]
Besifovir | [CAS]
1254032-66-0 | [Synonyms]
AR-11324
Netarsudil，Besifovir
Netarsudil Impurity 8
(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester | [Molecular Formula]
C28H27N3O3 | [MDL Number]
MFCD28502136 | [MOL File]
1254032-66-0.mol | [Molecular Weight]
453.53 |
| Chemical Properties | Back Directory | [Boiling point ]
711.9±60.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.84±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Netarsudil is a Rho kinase (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil increases outflow facility in human eyes through multiple mechanisms[1]. | [References]
[1] Ren R, et al. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6197-6209. DOI:10.1167/iovs.16-20189 |
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