| Chemical Properties | Back Directory | [Boiling point ]
840.5±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Viscous Liquid | [pka]
12.23±0.46(Predicted) | [color ]
Colorless to yellow |
| Hazard Information | Back Directory | [Description]
DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent. it can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions. | [Biological Activity]
DBCO-NHCO-PEG4-NH-Boc is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Cleavable | PEGs | Alkyl/ether | |
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