| Identification | Back Directory | [Name]
Benzamide, N-methyl-3-[[[4-(4-pyridinyl)benzoyl]amino]methyl]- | [CAS]
1256264-62-6 | [Synonyms]
PF4950834
PF-4950834
PF 4950834
Benzamide, N-methyl-3-[[[4-(4-pyridinyl)benzoyl]amino]methyl]- | [Molecular Formula]
C21H19N3O2 | [MOL File]
1256264-62-6.mol | [Molecular Weight]
345.39 |
| Chemical Properties | Back Directory | [Boiling point ]
619.7±55.0 °C(Predicted) | [density ]
1.193±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.28±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1]. | [IC 50]
ROCK2: 8.35 nM (IC50); ROCK1: 33.12 nM (IC50); PKA: 424 nM (IC50); PKCη: 756 nM (IC50) | [References]
[1] Rajagopalan LE, et al. Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity. J Pharmacol Exp Ther. 2010 Jun;333(3):707-16. DOI:10.1124/jpet.110.166033 |
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