| Identification | Back Directory | [Name]
2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide | [CAS]
1256493-34-1 | [Synonyms]
Dyng
o-4a
Dyngo-4a
Dyngo-49
Hydroxy-Dynasore
3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide | [Molecular Formula]
C18H14N2O5 | [MDL Number]
MFCD23704787 | [MOL File]
1256493-34-1.mol | [Molecular Weight]
338.31 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
8.28±0.40(Predicted) | [color ]
faint yellow to dark yellow | [InChI]
1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+ | [InChIKey]
UAXHPUSKEWEOAP-DJKKODMXSA-N | [SMILES]
Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O |
| Hazard Information | Back Directory | [Uses]
Hydroxy-Dynasore is an inhibitor of dynamin I and dynamin II. | [Definition]
ChEBI: Dyngo-4a is dynamin inhibitor. It has a role as an EC 3.6.5.5 (dynamin GTPase) inhibitor. | [Biochem/physiol Actions]
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). Apparently, Hydroxy-Dynasore prevents dynamin-mediated fission of endocytic vesicles from the plasma membrane. | [in vivo]
Hydroxy Dynasore (intraperitoneal injection; 30 mg/kg; 1.5-2 h before BoNT/A injection) provides protection again BoNT/A-induced paralysis in the phrenic nerve-hemidiaphragm twitch model in CD-1 mice[2]. | Animal Model: | CD-1 mice[2]. | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection; 1.5–2 h before BoNT/A injection | | Result: | Protected BoNT/A-induced paralysis in vivo. |
| [storage]
Store at -20°C |
|
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
SPIRO PHARMA
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www.spiropharma.com.cn |
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