| Identification | More | [Name]
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate | [CAS]
125700-67-6 | [Synonyms]
2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
HBTU
KNORR REAGENT
N-[(1H-BENZOTRIAZOL-1-YL)(DIMETHYL-AMINO)METHYLENE]-N-METHYL-METHANAMINIUM TETRAFLUOROBORATE
N,N,N',N'-TETRAMETHYL-O-(BENZOTRIAZOL-1-YL)URONIUM TETRAFLUOROBORATE
O-(1H-BENZO-1,2,3-TRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL-URONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-PENTAMETHYLENE-URONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
O-(1H-BENZOTRIAZOLE-1-YL) N,N,N',N'-TETRAMETHYL URONIUM TETRAFLUOROBORATE
O-(BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM TETRAFLUOROBORATE
O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE
TBPIPU
TBTU
TETRAFLUOROBORATE TBTU
benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate
O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRA-&
O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHY LURONIUM
TBTU,O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE | [EINECS(EC#)]
423-040-4 | [Molecular Formula]
C11H17BF4N5O | [MDL Number]
MFCD00077413 | [Molecular Weight]
322.09 | [MOL File]
125700-67-6.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO PALE CREAM FINE CRYSTALLINE POWDER | [Melting point ]
205 °C (dec.)(lit.)
| [storage temp. ]
2-8°C
| [solubility ]
acetonitrile: 0.1 g/mL, clear
| [form ]
Powder | [color ]
White to Almost white | [Water Solubility ]
Soluble in acetonitrile (100 mg/ml, clear, colorless), DMF (160.55 mg/ml, clear), and water (3 mg/ml at 20°C). | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [BRN ]
7066325 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1 | [InChIKey]
NQGZJNPFMLJDKU-UHFFFAOYSA-M | [SMILES]
[B+3]([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C | [LogP]
-2.65 at 21℃ | [CAS DataBase Reference]
125700-67-6(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen;Moisture sensitive | [EPA Substance Registry System]
1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1) (125700-67-6) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H228-H315-H319-H335 | [Precautionary statements ]
P210-P240-P241-P261-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,F | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R5:Heating may cause an explosion. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
1325 | [WGK Germany ]
3
| [F ]
8-10-21 | [Hazard Note ]
Irritant/Flammable | [HazardClass ]
4.1 | [PackingGroup ]
Ⅱ | [HS Code ]
29339900 | [Storage Class]
4.1A - Other explosive hazardous materials | [Hazard Classifications]
Flam. Sol. 1
Skin Sens. 1A |
| Hazard Information | Back Directory | [Chemical Properties]
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate is WHITE TO PALE CREAM FINE CRYSTALLINE POWDER
| [Uses]
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
| [Uses]
Coupling reagent for peptide synthesis causing low racemization. R. Knorr, A. Trzeciak, W. Bannwarth and D. Gillessen, THL 30, 1927 (1989) | [reaction suitability]
reaction type: Coupling Reactions |
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