| Hazard Information | Back Directory | [Description]
Tenovin-D3 is an inhibitor of sirtuin SirT2. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner. | [Uses]
Tenovin-D3 hydrochloride is a sirtuin SirT2 inhibitor that increases p21 (CDKN1A) expression in a p53 independent manner[1]. | [References]
[1] McCarthy AR, et al. Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner. Mol Cancer Ther. 2013 Apr;12(4):352-60. DOI:10.1158/1535-7163.MCT-12-0900 |
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