| Identification | Back Directory | [Name]
AM-0687 | [CAS]
1259522-94-5 | [Synonyms]
AM-0687
4-Quinolinecarboxamide, 2-[(1S)-1-[(6-amino-5-cyano-4-pyrimidinyl)amino]ethyl]-6-fluoro-N-methyl-3-(2-pyridinyl)- | [Molecular Formula]
C23H19FN8O | [MOL File]
1259522-94-5.mol | [Molecular Weight]
442.45 |
| Hazard Information | Back Directory | [Uses]
AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy[1]. | [IC 50]
PI3Kδ: 2.9 nM (IC50); PI3Kβ: 2840 nM (IC50); PI3Kγ: 3530 nM (IC50); PI3Kα: 17600 nM (IC50) | [References]
[1] Gonzalez-Lopez de Turiso F, et al. Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430). J Med Chem. 2016 Aug 11;59(15):7252-67. DOI:10.1021/acs.jmedchem.6b00827 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|