| Identification | Back Directory | [Name]
CouMarin Suberoylanilide HydroxaMic Acid | [CAS]
1260635-77-5 | [Synonyms]
CouMarin Suberoylanilide HydroxaMic Acid
N1-Hydroxy-N8-(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)octanediaMide
Octanediamide, N1-hydroxy-N8-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- | [Molecular Formula]
C18H22N2O5 | [MDL Number]
MFCD28138306 | [MOL File]
1260635-77-5.mol | [Molecular Weight]
346.378 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 5 mg/ml | [form ]
A crystalline solid | [Appearance]
Solid Powder |
| Hazard Information | Back Directory | [Description]
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes. | [Uses]
Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. | [Definition]
ChEBI: Coumarin-SAHA is a member of coumarins. | [IC 50]
HDAC8 | [Excitation / Emission Maximum]
325 nm/400 nm |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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