Identification | Back Directory | [Name]
GNF179 | [CAS]
1261114-01-5 | [Synonyms]
GNF179 2-amino-1-[3-(4-chloroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone 2-Amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone 2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one Ethanone, 2-amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]- | [Molecular Formula]
C22H23ClFN5O | [MDL Number]
MFCD28167758 | [MOL File]
1261114-01-5.mol | [Molecular Weight]
427.9 |
Chemical Properties | Back Directory | [Boiling point ]
656.2±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 125 mg/mL (292.12 mM) | [form ]
Powder | [pka]
7.94±0.29(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone also known as GNF 179 is used in the imaging of plasmodium parasites for next generation antimalarial drug discovery. | [in vivo]
GNF179 (15 mg/kg; p.o.; single dose) shows antimalarial activity in rodent malaria model[1]. Animal Model: | Na?ve Balb/C mice infected with P. berghei[1] | Dosage: | 15 mg/kg | Administration: | Oral, single dose | Result: | Protected against an infectious P. berghei sporozoite. |
Animal Model: | Na?ve Balb/C mice[1] | Dosage: | 3 or 20 mg/kg | Administration: | IV or PO (Pharmacokinetic Analysis) | Result: | Pharmacokinetics of GNF179 in na?ve Balb/C mice.
Dose | AUC(0-∞) (hrs*μM) | AUC/dose | t1/2 (hrs) | MRT (hrs) | CL (ml/min/kg) | Vss (L/kg) | C0 or Cmax (μM) | F (%) | 3 mg/kg i.v. | 8.88 | 3.0 | 8.9 | 9.0 | 22 | 11.8 | 6.1 | nd | 20 mg/kg p.o. | 20.70 | 1.0 | 8.4 | nd | nd | nd | 1.2 | 58 |
AUC, Area Under the Curve; T1/2, half life; CL, clearance; VSS, steady-state volume of distribution; C0, initial concentration; Cmax maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.
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| [IC 50]
Plasmodium | [storage]
Store at -20°C |
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Company Name: |
SPIRO PHARMA
|
Tel: |
|
Website: |
www.spiropharma.com.cn |
Company Name: |
BOC Sciences
|
Tel: |
16314854226 |
Website: |
www.bocsci.com |
Company Name: |
Musechem
|
Tel: |
+1-800-259-7612 |
Website: |
www.musechem.com |
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