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1261114-01-5

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1261114-01-5 Structure

1261114-01-5 Structure
IdentificationBack Directory
[Name]

GNF179
[CAS]

1261114-01-5
[Synonyms]

GNF179
2-amino-1-[3-(4-chloroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone
2-Amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone
2-amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one
Ethanone, 2-amino-1-[3-[(4-chlorophenyl)amino]-2-(4-fluorophenyl)-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]-
[Molecular Formula]

C22H23ClFN5O
[MDL Number]

MFCD28167758
[MOL File]

1261114-01-5.mol
[Molecular Weight]

427.9
Chemical PropertiesBack Directory
[Boiling point ]

656.2±55.0 °C(Predicted)
[density ]

1.36±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: ≥ 125 mg/mL (292.12 mM)
[form ]

Powder
[pka]

7.94±0.29(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

2-Amino-1-(3-((4-chlorophenyl)amino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethanone also known as GNF 179 is used in the imaging of plasmodium parasites for next generation antimalarial drug discovery.
[in vivo]

GNF179 (15 mg/kg; p.o.; single dose) shows antimalarial activity in rodent malaria model[1].

Animal Model:Na?ve Balb/C mice infected with P. berghei[1]
Dosage:15 mg/kg
Administration:Oral, single dose
Result:Protected against an infectious P. berghei sporozoite.
Animal Model:Na?ve Balb/C mice[1]
Dosage:3 or 20 mg/kg
Administration:IV or PO (Pharmacokinetic Analysis)
Result: Pharmacokinetics of GNF179 in na?ve Balb/C mice.
DoseAUC(0-∞)
(hrs*μM)		AUC/doset1/2
(hrs)		MRT
(hrs)		CL
(ml/min/kg)		Vss
(L/kg)		C0 or Cmax
(μM)		F (%)
3 mg/kg i.v.8.883.08.99.02211.86.1nd
20 mg/kg p.o.20.701.08.4ndndnd1.258

AUC, Area Under the Curve; T1/2, half life; CL, clearance; VSS, steady-state volume of distribution; C0, initial concentration; Cmax maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.
[IC 50]

Plasmodium
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

GNF179(1261114-01-5)1HNMR
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