| Hazard Information | Back Directory | [Description]
Enarodustat, also known as JTZ-951, is a prolyl hydroxylase inhibitor. JTZ-951 (enarodustat) stabilizes HIF-α protein and induces erythropoiesis without effects on the function of vascular endothelial growth factor. Enarodustat increases endogenous erythropoietin levels in the treatment of anemia associated with chronic kidney disease (CKD). JTZ-951 induces erythropoiesis without affecting VEGF function. JTZ-951 may be a new oral candidate that increases and maintains hemoglobin concentrations in renal anemia patients. | [Uses]
Enarodustat hydrochloride is a potent and orally active HIF/HIF Prolyl-Hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat hydrochloride has the potential for renal anemia treatment. | [in vivo]
Enarodustat hydrochloride (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1]. | [References]
[1] Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. DOI:10.1021/acsmedchemlett.7b00404 |
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