| Identification | Back Directory | [Name]
PF 956980 | [CAS]
1262832-74-5 | [Synonyms]
PF 956980
[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-pyrrolidin-1-ylmethanone
Methanone, [(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinyl- | [Molecular Formula]
C18H26N6O | [MOL File]
1262832-74-5.mol | [Molecular Weight]
342.44 |
| Hazard Information | Back Directory | [Uses]
PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent. | [Definition]
ChEBI: PF-956980 is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a methyl[(3R,4R)-4-methyl-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]nitrilo group. It is a potent JAK3-selective chemical probe. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a pyrrolopyrimidine, a tertiary amino compound, a N-acylpiperidine and a N-acylpyrrolidine. | [in vivo]
The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog
| Spesies | Dose (mg/kg) | Cl (mL/min/Kg) | Clunbound (mL/min/Kg) | Vss (L/Kg) | Terminal T1/2 (h) | Oral Bioavailability | |
| Rat i.v. | 0.5 | 48 | >48,000 | 0.8 | 2.1 | - | |
| Rat p.o. | 1 | - | - | - | - | <5% | |
| Dog i.v. | 0.1 | 18 | >18,000 | 1.0 | 2.0 | - | |
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| [IC 50]
JAK1: 2.2 μM (IC50); JAK2: 23.1 μM (IC50); JAK3: 59.9 μM (IC50) |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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