| Identification | Back Directory | [Name]
DL-AP4 sodium salt | [CAS]
1263093-79-3 | [Synonyms]
DL-AP4 sodium salt
DL-2-Amino-4-phosphonobutyricacidsodiumsalt
DLAP4 Sodium salt,DL AP4 Sodium salt,DL-AP-4 Sodium salt | [Molecular Formula]
C4H11NNaO5P | [MOL File]
1263093-79-3.mol | [Molecular Weight]
207.1 |
| Hazard Information | Back Directory | [Uses]
DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes[1][2]. | [storage]
Desiccate at RT | [References]
[1] Thomsen C, et al., L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase. Eur J Pharmacol. 1992 Nov 2;227(3):361-2. DOI:10.1016/0922-4106(92)90018-q
[2] Dolan RP, et al., Effects of ON channel blockade with 2-amino-4-phosphonobutyrate (APB) on brightness and contrast perception in monkeys. Vis Neurosci. 1994 Jan-Feb;11(1):23-32. DOI:10.1017/s095252380001107x |
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