| Identification | More | [Name]
2-Amino-3-bromo-6-methylpyridine | [CAS]
126325-46-0 | [Synonyms]
2-AMINO-3-BROMO-6-METHYLPYRIDINE
2-AMINO-3-BROMO-6-PICOLINE
3-BROMO-6-METHYLPYRIDIN-2-AMINE
3-BROMO-6-METHYL-PYRIDIN-2-YLAMINE
6-AMINO-5-BROMO-2-PICOLINE
BUTTPARK 43\57-93
TIMTEC-BB SBB005516
2-AMINO-3-BROMO-6-PICOLINE (2-AMINO-3-BROMO-6-METHYLPYRIDINE) | [Molecular Formula]
C6H7BrN2 | [MDL Number]
MFCD03095215 | [Molecular Weight]
187.04 | [MOL File]
126325-46-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
77-79°C | [Boiling point ]
238.5±35.0 °C(Predicted) | [density ]
1.5672 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Keep Cold | [form ]
Solid | [pka]
4.24±0.50(Predicted) | [color ]
Off-white | [Sensitive ]
Light Sensitive | [InChI]
InChI=1S/C6H7BrN2/c1-4-2-3-5(7)6(8)9-4/h2-3H,1H3,(H2,8,9) | [InChIKey]
JYWWGZAAXTYNRN-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(C)=CC=C1Br | [CAS DataBase Reference]
126325-46-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
2-Amino-3-bromo-6-methylpyridine
is a versatile chemical compound that plays a significant role in
various fields, particularly in pharmaceuticals and agrochemicals. | [Chemical Properties]
Light yellow Cryst | [Uses]
2-Amino-3-bromo-6-methylpyridine is recognized for its unique structure, which allows it to act as a key intermediate in the synthesis of biologically active molecules. Its bromine and amino functional groups enhance its reactivity, making it an essential building block for the development of new drugs and crop protection agents. | [Synthesis]
Step 1: Preparation of 2-amino-3-bromo-6-methylpyridine
32.4 g (0.3 mol) of 2-amino-6-methylpyridine was dissolved in 28 g of concentrated hydrochloric acid. Sulfuric acid and 120 ml of water were added to the mixture and the resulting solution was subsequently cooled to 0°C in an ice water bath. Over a period of 30 minutes, 52.8 g (0.33 mol) of bromine was slowly added dropwise to the cooled solution. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 20 minutes. Subsequently, the reaction solution was neutralized with cold aqueous NaOH. The resulting solid product was collected by filtration and purified by column chromatography using dichloromethane and ethyl acetate as eluents. Finally 31 g of 2-amino-3-bromo-6-methylpyridine was obtained in 55% yield. | [References]
[1] Patent: US5691348, 1997, A |
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