| Identification | Back Directory | [Name]
VTP-27999 (Hydrochloride) | [CAS]
1264191-73-2 | [Synonyms]
VTP-27999 HCl
VTP-27999 (Hydrochloride)
VTP27999; VTP 27999;VTP27999 HYDROCHLORIDE; VTP 27999 HYDROCHLORIDE
methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate hydrochloride
N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamic acid methyl ester hydrochloride (1:1)
Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1) | [Molecular Formula]
C26H42Cl2N4O5 | [MDL Number]
MFCD22741503 | [MOL File]
1264191-73-2.mol | [Molecular Weight]
561.55 |
| Hazard Information | Back Directory | [Description]
VTP-27999 Hydrochloride is a potent inhibitor of renin with IC50 value of 0.3 nM for human renin. | [Uses]
VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
IC50 value:
Target: Renin | [target]
human renin | [References]
[1] Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751
[2] New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. DOI:10.1161/HYPERTENSIONAHA.111.00967
[3] Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25. DOI:10.1021/ci200605k |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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