| Identification | Back Directory | [Name]
Benzene, 1-[(1Z)-2-chloro-2-nitroethenyl]-4-nitro- | [CAS]
127143-25-3 | [Synonyms]
FBPase-IN-2
Benzene, 1-[(1Z)-2-chloro-2-nitroethenyl]-4-nitro- | [Molecular Formula]
C8H5ClN2O4 | [MOL File]
127143-25-3.mol | [Molecular Weight]
228.59 |
| Hazard Information | Back Directory | [Uses]
FBPase-IN-2 (HS36) is a potent Fructose-1,6-bisphosphatase (FBPase) covalent inhibitor with an IC50 of 0.15 μM. FBPase-IN-2 reduces glucose production in hepatocytes. FBPase-IN-2 can be used for type 2 diabetes mellitus research[1]. | [References]
[1] Han X, et al. Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase. Bioorg Med Chem. 2020 Sep 15;28(18):115624. DOI:10.1016/j.bmc.2020.115624 |
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