| Identification | Back Directory | [Name]
Managlinat dialanetil | [CAS]
280782-97-0 | [Synonyms]
CS-917
MB 06322
Managlinat dialanetil
Managlinat Dialanetil/CS-917
L-Alanine, N,N'-[[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphinylidene]bis-, 1,1'-diethyl ester | [Molecular Formula]
C21H33N4O6PS | [MDL Number]
MFCD20134201 | [MOL File]
280782-97-0.mol | [Molecular Weight]
500.55 |
| Chemical Properties | Back Directory | [Boiling point ]
634.8±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.13±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2]. | [in vivo]
Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1].
| [References]
[1] Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58. PMID:17907062 |
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