| Identification | More | [Name]
1-ISOPROPYL-PIPERIDIN-4-YLAMINE | [CAS]
127285-08-9 | [Synonyms]
1-ISOPROPYLPIPERIDIN-4-AMINE
1-ISOPROPYL-PIPERIDIN-4-YLAMINE
4-AMINO-1-ISOPROPYL PIPERIDINE
AKOS B016068
ART-CHEM-BB B016068
N-ISO-PROPYL-4-AMINO-PIPERIDINE
TIMTEC-BB SBB009390
N-Iso-proppyl-4-amino-piperidine | [Molecular Formula]
C8H18N2 | [MDL Number]
MFCD03411606 | [Molecular Weight]
142.24 | [MOL File]
127285-08-9.mol |
| Chemical Properties | Back Directory | [Boiling point ]
173.2±8.0 °C(Predicted) | [density ]
0.904±0.06 g/cm3(Predicted) | [refractive index ]
1.4720 to 1.4760 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
clear liquid | [pka]
10.51±0.20(Predicted) | [color ]
Colorless to Almost colorless | [InChI]
InChI=1S/C8H18N2/c1-7(2)10-5-3-8(9)4-6-10/h7-8H,3-6,9H2,1-2H3 | [InChIKey]
ZRQQXFMGYSOKDF-UHFFFAOYSA-N | [SMILES]
N1(C(C)C)CCC(N)CC1 | [CAS DataBase Reference]
127285-08-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2920 8/3/PG II | [HazardClass ]
IRRITANT | [PackingGroup ]
II | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Uses]
1-Isopropylpiperidin-4-amine is used as a pharmaceutical intermediate compound for the preparation of antiviral compounds or small molecule bioactive inhibitors. | [Synthesis]
GENERAL METHOD: Compound I-5 (240 mg) was dissolved in hexafluoroisopropanol (HFIP, 8 mL) and 10% palladium/carbon (Pd/C, 120 mg) was added. The reaction mixture was stirred at room temperature for 20 h under hydrogen atmosphere (1 atm). Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give the yellow oily product I-6 (100 mg, 75% yield). | [References]
[1] European Journal of Medicinal Chemistry, 2017, vol. 132, p. 26 - 41
[2] Patent: EP1489078, 2004, A1. Location in patent: Page 130 |
|
|