| Identification | Back Directory | [Name]
2-CHLORO-4-METHOXYBENZONITRILE | [CAS]
127666-99-3 | [Synonyms]
BUTTPARK 120\07-70
3-Chloro-4-cyanoanisole
2-CHLORO-4-METHOXYBENZONITRILE
Benzonitrile,2-chloro-4-methoxy-
2-chloro-4-Methoxy benzene nitrile
2-BROMO-7-METHYLH-IMIDAZO[1,4-A]PYRIDINE*
2-chloro-4-(trifluoromethoxy)benzonitrile
3-Chloro-4-cyanoanisole, 2-Chloro-p-anisonitrile | [Molecular Formula]
C8H6ClNO | [MDL Number]
MFCD00156133 | [MOL File]
127666-99-3.mol | [Molecular Weight]
167.59 |
| Chemical Properties | Back Directory | [Melting point ]
71-75°C | [Boiling point ]
296.6±20.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white crystalline | [Synthesis]
General procedure for the synthesis of 2-chloro-4-methoxybenzonitrile from 2-chloro-4-hydroxybenzonitrile and iodomethane: To a stirred solution of 2-chloro-4-hydroxybenzonitrile (2.5 g, 16 mmol) in DMF (25 mL) was slowly added NaH (0.431 g, 18.0 mmol) at 0 °C. After 30 min, iodomethane (3.47 g, 24.4 mmol), followed by continued stirring of the reaction mixture for 1 h at room temperature. After completion of the reaction, the reaction mixture was quenched with ice water and extracted with ether. The organic layer was washed sequentially with water and saturated NaCl solution, dried over Na2SO4 and concentrated in vacuum to afford the target product 2-chloro-4-methoxybenzonitrile as a brown solid (2.7 g, 98% yield). | [References]
[1] Patent: WO2010/65760, 2010, A1. Location in patent: Page/Page column 133-134
[2] Patent: WO2006/8046, 2006, A1. Location in patent: Page/Page column 47 |
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