| Identification | More | [Name]
2-CHLORO-4-METHOXYPHENOL | [CAS]
18113-03-6 | [Synonyms]
2-CHLORO-4-METHOXYPHENOL
3-CHLORO-4-HYDROXYANISOLE
2-Chlorohydroquinonemonomethylether
2-chloro-4-methoxylphenol
| [EINECS(EC#)]
242-007-3 | [Molecular Formula]
C7H7ClO2 | [MDL Number]
MFCD00070773 | [Molecular Weight]
158.58 | [MOL File]
18113-03-6.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO LIGHT YELLOW CRYST. LOW MELTING SOLID | [Melting point ]
41-44 °C(lit.) | [Boiling point ]
241°C (rough estimate) | [density ]
1.153 g/mL at 25 °C(lit.)
| [Fp ]
185 °F
| [storage temp. ]
Sealed in dry,2-8°C | [form ]
Crystalline Low Melting Solid | [pka]
8.98±0.18(Predicted) | [color ]
White to light yellow | [Specific Gravity]
1.153 | [BRN ]
1936412 | [CAS DataBase Reference]
18113-03-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29071990 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO LIGHT YELLOW CRYST. LOW MELTING SOLID | [Synthesis]
General procedure for the synthesis of 2-chloro-4-methoxyphenol from 4,4-dimethoxycyclohexa-2,5-dien-1-one: 4,4-dimethoxycyclohexa-2,5-dien-1-one (1.0 mmol) was added to the reaction vessel, followed by the addition of a solution of 1,4-dioxane in 4N HCl (0.5 mL, 2 mmol) dropwise. The yellow color of the reaction mixture faded rapidly. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was diluted with ethyl acetate (10 mL) and washed with saturated aqueous NaHCO3 solution (5 mL). The organic layer was dried with anhydrous Na2SO4, filtered and concentrated to give 2-chloro-4-methoxyphenol in 95% yield. If necessary, it can be purified by column chromatography using ethyl acetate/hexane gradient elution. | [References]
[1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 18, p. 2854 - 2858
[2] Tetrahedron Letters, 2016, vol. 57, # 1, p. 15 - 19 |
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