| Identification | Back Directory | [Name]
Rhosin (hydrochloride) | [CAS]
1281870-42-5 | [Synonyms]
Rhosin HCl
G04 HYDROCHLORIDE
Rhosin (hydrochloride)
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride | [Molecular Formula]
C20H19ClN6O | [MDL Number]
MFCD18794648 | [MOL File]
1281870-42-5.mol | [Molecular Weight]
394.86 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol | [form ]
A solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Rhosin hydrochloride is the hydrochloride salt of rhosin (CAS# 1173671-63-0) which is a D-tryptophan derivative and an inhibitor of Rho GTPases with potential application in reversing chemotherapy resistance in diffuse-type gastric adenocarinoma. | [in vivo]
Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice[3].
Rhosin (30 μM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice[3]. | Animal Model: | D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background[3] | | Dosage: | 40 mg/kg | | Administration: | I.p. | | Result: | Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|