| Identification | Back Directory | [Name]
3'-Azido-3'-deoxy-5-methylcytidine | [CAS]
1282040-14-5 | [Synonyms]
3'-Azido-3'-deoxy-5-methylcytidin
3'-Azido-3'-deoxy-5-methylcytidine | [Molecular Formula]
C10H14N6O4 | [MOL File]
1282040-14-5.mol | [Molecular Weight]
282.26 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
HIV-1: 0.06 μM (EC50, in PBM cells); XMRV: 43.5 μM (CC50, in MCF-7 cells) | [storage]
Store at -20°C | [References]
[1] Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948. DOI:10.1371/journal.pone.0009948 |
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