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1282040-14-5

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1282040-14-5 Structure

1282040-14-5 Structure
IdentificationBack Directory
[Name]

3'-Azido-3'-deoxy-5-methylcytidine
[CAS]

1282040-14-5
[Synonyms]

3'-Azido-3'-deoxy-5-methylcytidin
3'-Azido-3'-deoxy-5-methylcytidine
[Molecular Formula]

C10H14N6O4
[MOL File]

1282040-14-5.mol
[Molecular Weight]

282.26
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50]

HIV-1: 0.06 μM (EC50, in PBM cells); XMRV: 43.5 μM (CC50, in MCF-7 cells)
[storage]

Store at -20°C
[References]

[1] Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948. DOI:10.1371/journal.pone.0009948
Spectrum DetailBack Directory
[Spectrum Detail]

3'-Azido-3'-deoxy-5-methylcytidine(1282040-14-5)1HNMR
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