| Identification | Back Directory | [Name]
3-((4-(TrifluoroMethyl)phenyl)aMino)benzoic acid | [CAS]
1284180-11-5 | [Synonyms]
AKR1C3-IN-4
Brassicasterol Impurity 23
3-[4-(trifluoromethyl)anilino]benzoic acid
3-((4-(TrifluoroMethyl)phenyl)aMino)benzoic acid
3-((4-(Tri?uoromethyl)phenyl)amino) benzoic acid
Benzoic acid, 3-[[4-(trifluoromethyl)phenyl]amino]-
AKR1C2,resistant,CRPC,inhibit,AKR1C3IN4,AKR1C3 IN 4,cancer,AKR1C3,AKR-1C3-IN-4,prostate,Inhibitor,aldo-keto,1C3,castrate,reductase | [Molecular Formula]
C14H10F3NO2 | [MDL Number]
MFCD28016823 | [MOL File]
1284180-11-5.mol | [Molecular Weight]
281.23 |
| Chemical Properties | Back Directory | [Boiling point ]
402.8±45.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
Solid | [pka]
4.22±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research[1]. | [References]
[1] Adegoke O Adeniji, et al. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem. 2012 Mar 8;55(5):2311-23. DOI:10.1021/jm201547v |
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| Company Name: |
BePharm Ltd
|
| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|