| Identification | Back Directory | [Name]
C12-Sphingosine | [CAS]
128427-86-1 | [Synonyms]
C12-Sphingosine
Sphingosine (d12:1)
4-Dodecene-1,3-diol, 2-amino-, (2S,3R,4E)- | [Molecular Formula]
C12H25NO2 | [MOL File]
128427-86-1.mol | [Molecular Weight]
215.33 |
| Chemical Properties | Back Directory | [Boiling point ]
364.8±42.0 °C(Predicted) | [density ]
0.980±0.06 g/cm3(Predicted) | [solubility ]
DMF: 10 mg/mL; DMSO: 2 mg/ml; Ethanol: miscible | [form ]
A crystalline solid | [pka]
11.83±0.45(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Sphingosine (d12:1) is a short-chain sphingolipid. It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner. Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) , lactosylceramide (Item Nos. 27197 | 16983), galactosylceramide , and a variety of gangliosides in mouse cerebellar granule cells. [Matreya, LLC. Catalog No. 1838] | [Uses]
(2S,3R,4E)-2-Amino-4-dodecene-1,3-diol acts as a sphingolipid base that inhibits sphingosine kinase. | [References]
[1] E C MANDON. Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.[J]. European journal of biochemistry, 1991, 198 3: 667-674. DOI: 10.1111/j.1432-1033.1991.tb16065.x
[2] G. ECHTEN. Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases.[J]. The Journal of Biological Chemistry, 1990, 120 1: 9333-9339. DOI: 10.1016/s0021-9258(19)38853-2 |
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