| Identification | Back Directory | [Name]
LpxC inhibitor 1a | [CAS]
1289620-49-0 | [Synonyms]
PF-04753299
LpxC inhibitor 1a
PF-04753299 >=98%
[1,1'-Biphenyl]-4-butanamide, N-hydroxy-α-methyl-α-(methylsulfonyl)-, (αR)- | [Molecular Formula]
C18H21NO4S | [MDL Number]
MFCD22683864 | [MOL File]
1289620-49-0.mol | [Molecular Weight]
347.43 |
| Chemical Properties | Back Directory | [density ]
1.249±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 34.7mg/mL | [form ]
A solid | [pka]
8.18±0.50(Predicted) | [color ]
White to off-white | [InChI]
1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | [InChIKey]
GDYIQUFNICPYHF-GOSISDBHSA-N | [SMILES]
O=C(NO)[C@@](S(=O)(C)=O)(C)CCC(C=C1)=CC=C1C2=CC=CC=C2 |
| Hazard Information | Back Directory | [Description]
PF-04753299 is a potent and selective inhibitor of LpxC (UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase) that is effective in a murine of gram-negative bacteria infection model. | [Uses]
PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine?deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection[1]. | [References]
[1] Constance M John, et al. Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors. J Antimicrob Chemother. 2018 Aug 1;73(8):2064-2071. DOI:10.1093/jac/dky151 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|