| Identification | Back Directory | [Name]
RIPK2 inhibitor 1 | [CAS]
1290490-78-6 | [Synonyms]
RIPK2 inhibitor 1
Benzamide, 3-(benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]- | [Molecular Formula]
C25H22N4O2 | [MOL File]
1290490-78-6.mol | [Molecular Weight]
410.47 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
powder | [color ]
white to very dark gray | [InChI]
1S/C25H22N4O2/c1-17-11-12-20(16-22(17)28-24(30)18-7-4-3-5-8-18)25(31)27-21-10-6-9-19(15-21)23-26-13-14-29(23)2/h3-16H,1-2H3,(H,27,31)(H,28,30) | [InChIKey]
OIIYBZHRYXJCHR-UHFFFAOYSA-N | [SMILES]
CC1=CC=C(C(NC2=CC(C3=NC=CN3C)=CC=C2)=O)C=C1NC(C4=CC=CC=C4)=O |
| Hazard Information | Back Directory | [Uses]
RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor. RIPK2-IN-3 inhibits recombinant truncated RIPK2 with an IC50 of 6.39 μM. RIPK2-IN-3 can be used for research of inflammation and cancer[1]. | [Biological Activity]
RIPK2 inhibitor 1 is a potent and selective inhibitor of Receptor interacting protein kinase 2 (RIPK2) th at potently inhibit NFKB activity and the proliferation of cancer cell lines. RIPK2 inhibitor 1 inhibits intestinal and lung inflammation in rodent models. | [storage]
Store at -20°C | [References]
[1] Shairaz BAKSH, et al. Ripk2 inhibitors. WO2019161495. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
ChemOrigin Pharm
|
| Tel: |
021-15026428026 15026428026 |
| Website: |
chemorigin.com/ |
|