| Identification | Back Directory | [Name]
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide | [CAS]
1292285-54-1 | [Synonyms]
SPRi 3
SPR inhibitor 3
N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
Acetamide, N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxy- | [Molecular Formula]
C14H18N2O3 | [MDL Number]
MFCD32215304 | [MOL File]
1292285-54-1.mol | [Molecular Weight]
262.3 |
| Chemical Properties | Back Directory | [Boiling point ]
561.9±50.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM,Ethanol: 100 mM | [form ]
A solid | [pka]
10.14±0.40(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Latremoliere A, et al. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 2015 Jun 17;86(6):1393-406. DOI:10.1016/j.neuron.2015.05.033
[2] Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568. DOI:10.1038/s41586-018-0701-2
[3] Haruki H, et al. Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. J Biol Chem. 2016 Jan 8;291(2):652-7. DOI:10.1074/jbc.C115.680488 |
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