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129273-38-7

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129273-38-7 Structure

129273-38-7 Structure
IdentificationMore
[Name]

Perospirone hydrochloride
[CAS]

129273-38-7
[Synonyms]

(3ar,7as)-2-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione hydrochloride
PEROSPIRONE HYDROCHLORIDE
PEROSPIRONE HYDROCHLORIDE DIHYDRATE
PEROSPIRONE HYDROCHLORIDE HYDRATE
1h-isoindole-1,3(2h)-dione,2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)but
monohydrochloride,cis-yl)hexahydro
sm-9018
(3aR,7aS)-rel-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H- isoindole-1,3(2H)-dione Hydrochloride Trihydrate
Lulla
Perospirone Hydrochloride Trihydrate
(3aR,7aS)-2-[4-[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione hydrochloride
Lullan
[Molecular Formula]

C23H35ClN4O4S
[MDL Number]

MFCD08457543
[Molecular Weight]

499.07
[MOL File]

129273-38-7.mol
Chemical PropertiesBack Directory
[Appearance]

White Solid
[Melting point ]

95-970C
[storage temp. ]

-20°C Freezer
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Usage]

Serotonin (5-HT2) and dopamine (D2) antagonist (SDA)
[InChIKey]

HIZFAPMOZFYELI-GNXQHMNLNA-N
[SMILES]

C(N1CCN(C2=NSC3C=CC=CC2=3)CC1)CCCN1C([C@@]2([H])CCCC[C@@]2([H])C1=O)=O.Cl |&1:21,27,r|
[CAS DataBase Reference]

129273-38-7(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P264-P270-P301+P312-P330-P501
[WGK Germany ]

WGK 1
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Acute Tox. 4 Oral
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

Serotonin (5-HT2) and dopamine (D2) antagonist (SDA)
[Biological Activity]

Perospirone (SM-9018) is a typical neuroleptic (antipsychotic) agent th at displays high affinity for 5-HT2D2 and 5-HT1A receptors (Ki = 0.611.4 and 2.9-1.8 nMrespectively)moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nMrespectively)while exhibiting much reduced affinity for alpha 2 (Ki = 408 nM) and little affinity toward muscarinicopiateglutamatephencyclidinebenzodiazepine or GABAA receptors (Ki >1 μM). SM-9018 antagonizes both D2-dependent (e.g. methamphetamine-induced hyperactivityapomorphine-induced stereotypy) and 5-HT2-mediated (e.g. tryptamine-induced clonic seizure) activities in vivowhile exhibiting very low cataleptogenic and central depressant activities commonly observed with two other neurolepticshaloperidol and chlorpromazine.
[IC 50]

5-HT2A Receptor: 0.6 nM (Ki); D2 Receptor: 1.4 nM (Ki); 5-HT1A Receptor: 2.9 nM (Ki); 5-HT1 Receptor: 18 nM (Ki); D1 Receptor: 41 nM (Ki)
Spectrum DetailBack Directory
[Spectrum Detail]

Perospirone hydrochloride(129273-38-7)1HNMR
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