| Identification | Back Directory | [Name]
1H-Imidazole-4-carboxamide, 5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-[[3-(trifluoromethyl)phenyl]methyl]- | [CAS]
1295541-87-5 | [Synonyms]
DUN41875
SCD1 inhibitor-4
5-Methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-(3-(trifluoromethyl)benzyl)-1H-imidazole-4-carboxamide
1H-Imidazole-4-carboxamide, 5-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1-[[3-(trifluoromethyl)phenyl]methyl]- | [Molecular Formula]
C17H16F3N5O | [MDL Number]
MFCD34474129 | [MOL File]
1295541-87-5.mol | [Molecular Weight]
363.34 |
| Chemical Properties | Back Directory | [Boiling point ]
458.0±45.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [solubility ]
Methanol: Soluble | [form ]
Solid | [pka]
12.42±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
DUN41875, also known as SCD1 inhibitor-4, is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes. DUN41875 was first reported in Bioorgan.Med. Chem. Lett. (2011), 21(6), 1621-1625. This product has no formal name at the moment. | [Uses]
SCD1 inhibitor-4 is a potent, orally active stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes[1]. | [in vivo]
SCD1 inhibitor-4 (1~30 mg/kg) shows a dose-dependent decrease in desaturation index with a 55 % reduction at 1 mg/kg and 85% reduction at the 10 and 30 mg/kg doses[1]. | [References]
[1] Atkinson KA, et al. N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors. Bioorg Med Chem Lett. 2011;21(6):1621-1625. DOI:10.1016/j.bmcl.2011.01.113 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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