| Hazard Information | Back Directory | [Description]
CTK7A is a novel water-soluble inhibitor of the histone acetyltransferase (HAT) activity of p300, inhibiting tumor growth in xenografted mice. | [Uses]
CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer treatment research[1]. | [References]
[1] Rath S, et al. CTK7A, a curcumin derivative, can be a potential candidate for targeting HIF-1α/p300 complex: Evidences from in vitro and computational studies[J]. Biophysical Chemistry, 2022, 287: 106828. DOI:10.1016/j.bpc.2022.106828 |
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