| Identification | Back Directory | [Name]
Target Protein-binding moiety 4 | [CAS]
1300019-38-8 | [Synonyms]
I-BET762 carboxylic acid
GSK525762A carboxylic acid
Molibresib carboxylic acid
PROTAC BRD4-binding moiety 2
Target Protein-binding moiety 4
I BET762 carboxylic acid,I-BET-762 carboxylic acid,IBET762 carboxylic acid
4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid, 6-(4-chlorophenyl)-8-methoxy-1-methyl-, (4S)- | [Molecular Formula]
C20H17ClN4O3 | [MOL File]
1300019-38-8.mol | [Molecular Weight]
396.83 |
| Chemical Properties | Back Directory | [Boiling point ]
648.3±65.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 7.14 mg/mL (17.99 mM) | [form ]
Solid | [pka]
4.12±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Target Protein-binding moiety 4 is a BRD4(1) inhibitor with an IC50 of 7.9 μM. Target Protein-binding moiety 4 (compound 32) is a BRD4 (1) inhibitor with an IC50 of 7.9 μM[1]. | [Uses]
I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1[1]. | [IC 50]
BRD4: 5.1 (pIC50) | [storage]
Store at -20°C | [References]
[1]. Yifei Yang, et al. Combined pharmacophore models as virtual screening protocol against BRD4(1) inhibitor. Medicinal Chemistry Research (2016), 25(4), 585-595. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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