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1309451-06-6

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1309451-06-6 Structure

1309451-06-6 Structure
IdentificationBack Directory
[Name]

Benzyl-PEG2-CH2CO2tBu
[CAS]

1309451-06-6
[Synonyms]

BnO-PEG1-CH2CO2tBu
Benzyl-PEG2-CH2CO2tBu
tert-butyl 2-(2-(benzyloxy)ethoxy)acetate
tert-butyl 2-(2-(benzyloxy)ethoxy)acetate(WXPC0080)
[Molecular Formula]

C15H22O4
[MDL Number]

MFCD28015768
[MOL File]

1309451-06-6.mol
[Molecular Weight]

266.33
Chemical PropertiesBack Directory
[Boiling point ]

354.2±22.0 °C(Predicted)
[density ]

1.048±0.06 g/cm3(Predicted)
Hazard InformationBack Directory
[Description]

Benzyl-PEG2-CH2CO2tBu is a PEG linker containing a benzyl group and a t-butyl protected carbonyl. Both the benzyl and t-Butyl group can be removed under acidic conditions. The carboxylic acid can be reacted with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
[Uses]

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs; Alkyl/ether
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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