| Identification | Back Directory | [Name]
Cbz-N-amido-PEG3-acid | [CAS]
1310327-18-4 | [Synonyms]
CBZ-AEEEP
CBZ-NH-PEG3-acid
Cbz-NH-PEG3-C2-acid
CBZ-N-AMIDO-PEG3-COOH
CbzNH-PEG3-CH2CH2COOH
Cbz-N-amido-PEG3-acid
CBZ-NH-PEG3-propionic acid
CBZ-12-amino-4,7,10-trioxadodecanoic acid
3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid
5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(phenylmethyl) ester | [Molecular Formula]
C17H25NO7 | [MDL Number]
MFCD28142484 | [MOL File]
1310327-18-4.mol | [Molecular Weight]
355.38 |
| Hazard Information | Back Directory | [Description]
Cbz-N-amido-PEG3-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | [Uses]
Cbz-NH-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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