| Identification | Back Directory | [Name]
Cbz-N-amido-PEG8-acid | [CAS]
1334177-87-5 | [Synonyms]
CBZ-NH-PEG8-COOH
CBZ-NH-PEG8-acid
Cbz-NH-PEG8-C2-acid
Cbz-N-amido-PEG8-acid
CBZ-N-AMIDO-PEG8-COOH
CBZ-NH-PEG8-CH2CH2COOH
CBZ-NH-PEG8-propionic acid
3-Oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 1-(phenylmethyl) ester | [Molecular Formula]
C27H45NO12 | [MDL Number]
MFCD11041145 | [MOL File]
1334177-87-5.mol | [Molecular Weight]
575.65 |
| Chemical Properties | Back Directory | [Boiling point ]
681.2±55.0 °C(Predicted) | [density ]
1.165±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Cbz-N-amido-PEG8-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | [Uses]
Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Adamas Reagent, Ltd.
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4006009262 13023226327 |
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T&W GROUP
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www.trustwe.com/ |
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Henan Alpha Chemical Co., Ltd.
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