| Identification | Back Directory | [Name]
5,8-Dioxa-2,11-diazaheptadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester | [CAS]
1310327-20-8 | [Synonyms]
PROTAC Linker 30
Boc-NH-PEG2-C2-amido-C4-acid
2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazaicosan-20-oic acid
5,8-Dioxa-2,11-diazaheptadecanedioic acid, 12-oxo-, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C17 H32 N2 O7 | [MDL Number]
MFCD32201087 | [MOL File]
1310327-20-8.mol | [Molecular Weight]
376.45 |
| Hazard Information | Back Directory | [Uses]
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21. |
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