| Identification | Back Directory | [Name]
NB-598 | [CAS]
131060-14-5 | [Synonyms]
Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl- | [Molecular Formula]
C27H31NOS2 | [MDL Number]
MFCD00898838 | [MOL File]
131060-14-5.mol | [Molecular Weight]
449.67 |
| Chemical Properties | Back Directory | [Melting point ]
~60 °C
| [Boiling point ]
530.7±50.0 °C(Predicted) | [density ]
1.122±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO: 14 mg/mL
| [form ]
solid
| [pka]
7.04±0.50(Predicted) | [color ]
white
| [InChI]
1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+ | [InChIKey]
KIRGLCXNEVICOG-SOFGYWHQSA-N | [SMILES]
[s]1c(cc(c1)c3c[s]cc3)COc2cc(ccc2)CN(CC)C\C=C\C#CC(C)(C)C |
| Hazard Information | Back Directory | [Uses]
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) th at suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumorssuch as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells. | [References]
[1] Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. DOI:10.1210/en.2008-0161
[2] Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. DOI:10.1016/0006-2952(93)90418-v
[3] Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51. PMID:8504141 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|