| Identification | Back Directory | [Name]
isoleucyl-lysyl-valyl-alanyl-valine | [CAS]
131167-89-0 | [Synonyms]
Laminin-1 peptide
H-Ile-Lys-Val-Ala-Val-OH
isoleucyl-lysyl-valyl-alanyl-valine
Laminin α-1 Chain (2099-2103) (human)
L-Isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine
L-Valine, L-isoleucyl-L-lysyl-L-valyl-L-alanyl- | [Molecular Formula]
C25H48N6O6 | [MOL File]
131167-89-0.mol | [Molecular Weight]
528.69 |
| Hazard Information | Back Directory | [Uses]
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. | [IC 50]
ERK1; ERK2; Akt | [References]
[1] Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267(20):14118-21. PMID:1629212
[2] Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47(2):133-45. DOI:10.1111/cpr.12094 |
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