| Identification | Back Directory | [Name]
Benzonitrile, 2-[[3-[(3R)-3-amino-1-piperidinyl]-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl]methyl]-4-fluoro- | [CAS]
1312954-58-7 | [Synonyms]
Benzonitrile, 2-[[3-[(3R)-3-amino-1-piperidinyl]-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl]methyl]-4-fluoro- | [Molecular Formula]
C17H19FN6O | [MOL File]
1312954-58-7.mol | [Molecular Weight]
342.37 |
| Hazard Information | Back Directory | [Uses]
Fotagliptin is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). Fotagliptin displays great security in rat and dog. Fotagliptin can be used for Type 2 diabetes mellitus research[1]. | [in vivo]
Fotagliptin (33 mg/kg or 110 mg/kg) is safe for rat and dog at different doses respectively[1].
| [IC 50]
DPP-4: 2.27 nM (IC50) | [References]
[1] Wang Z, et al. Development and validation of a UPLC-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine. Bioanalysis. 2017 Feb;9(4):381-393. DOI:10.4155/bio-2016-0243 |
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