ChemicalBook--->CAS DataBase List--->1313206-42-6

1313206-42-6

1313206-42-6 Structure

1313206-42-6 Structure
IdentificationBack Directory
[Name]

Polatuzumab vedotin
[CAS]

1313206-42-6
[Synonyms]

Polatuzumab vedotin
Research Grade Polatuzumab(DHE26301)
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Polatuzumab vedotin solution is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin solution has the potential for the research of Large B-cell lymphomas (LBCL)[1].
[References]

[1] Liebers N, et al. Polatuzumab vedotin as a salvage and bridging treatment in relapsed or refractory large B-cell lymphomas. Blood Adv. 2021 Jul 13;5(13):2707-2716. DOI:10.1182/bloodadvances.2020004155
[2] Li D, et al. Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin. Br J Pharmacol. 2019 Oct;176(19):3805-3818. DOI:10.1111/bph.14784
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